New testing finds synergistic combination leads to toxicity in nanomaterial

A new study finds reason for caution -- a clear emergence of toxicity -- in nanomaterial product formulations, but it also provides an early testing technique that could help the industry continue to move forward. the researchers re-examined the toxicity of nanoparticles that had been studied as part of the Safer Nanomaterials and Nanomanufacturing Initiative, which was funded by the Air Force Research Laboratory.

The National Science Foundation and National Institutes of Health supported the recent work. The cause of the synergistic toxicity was discovered when materials were analyzed with diffusion-ordered NMR spectroscopy, an adaptation of nuclear magnetic resonance that reveals how particles move, or diffuse, in solution.

As increasing amounts of surfactants were added, the researchers observed that the particles diffused more slowly because the surfactant assembles on the outside of the gold nanoparticles, leading to both increased uptake and toxicity, driven by surface structure, in the zebrafish. The technique harnesses molecular design principles to produce safer chemicals, reduce toxicity and minimize waste. And anticipating your research at International Conference on Nanomedicine and Nanotechnology in Health Care will pays you unforgettable experience while attending the at Istanbul, Turkey.

A New long-acting approach for malaria prophylaxis developed using nanomedicine approach.

Every year, malaria afflicts hundreds of millions of people and kills hundreds of thousands of children. Despite considerable success in reducing the worldwide prevalence of malaria, its incidence in visitors to endemic areas has continued to rise steadily.

Currently, the best available prevention of malaria requires oral dosing of antimalarial tablets. Chronic oral dosing of these medicines has significant complications because healthy people need to strictly adhere to the medication in order for effective prophylaxis to occur. The study, led by Pharmacologist aimed to utilize nanotechnology to improve the delivery of an existing antimalarial drug via a novel injectable format that can maintain blood concentration of the drug for weeks or months following a single dose.

Nanotechnology is the manipulation of matter on an atomic, molecular, and supramolecular scale. Nanomedicine is the application of nanotechnology to the diagnosis, prevention or treatment of disease in the human body.Solid Drug Nanoparticles (SDNs) are a nanotechnology with favourable characteristics to enhance drug exposure and improve the treatment or prevention of several diseases, including HIV and malaria. These particles have an approximate diameter that is 1/500th the width of a human hair, and once injected into the muscle, establish a drug depot that releases drug into the bloodstream over an extended period of time.

Through the use of this technology the trans-Atlantic research team developed an LAI version of a daily anti-malarial tablet (atovaquone) which provided prophylactic blood concentrations in mice for a period of 28 days. Moreover, mice injected with the nanomedicine were completely protected from the malaria parasite when exposed during this time, and since mice eliminate the drug much more rapidly in humans, a much longer duration of protection might be expected in people. ME conferences provides an endless opportunities to network with fellow attendees and get exposed to International Conference on Nanomedicine and Nanotechnology in Health Care, May 27-28, 2019 Istanbul, Turkey.

Revolutionary medical dressing uses nanotechnology to fight infection.

Researchers are using nanotechnology           to develop a medical dressing which will detect and treat infection in wounds. Scientists in the UK are working together with teams across Europe and Australia to create an advanced wound dressing. The dressing will work by releasing antibiotics from nanocapsules triggered by the presence of disease-causing pathogenic bacteria, which will target treatment before the infection takes hold. The dressing will also change colour when the antibiotic is released, alerting healthcare professionals that there is infection in the wound.

This is an important step in treating burns patients, particularly children, where infections can lead to toxic shock syndrome, a potentially fatal condition. The Bacteriosafe project includes chemists, cell biologists, clinicians and engineers. They will not only develop the dressing, but will also work with industry on a pre-pilot scale manufacturing process, so they could be available on the market within a few years after completion of the project. The dressing is only triggered by disease-causing bacteria, which produce toxins that break open capsules containing the antibiotics and dye. This means that antibiotics are only released when needed, which reduces the risk of the evolution of new antibiotic-resistant super-bugs such as MRSA.

This advanced dressing will speed up treatment because it is automatically triggered to release antibiotics only when the wound becomes infected, meaning that the dressing will not need to be removed, thereby increasing the chances of the wound healing without scarring. The dressing could also be used for other types of wound, such as ulcers or by the military on the battlefield.

The researchers have already tested fabric coated with the nanocapsules, which are just one millionth of a millimetre in size. They have been shown to react specifically to harmful bacteria. Over the next four years the European team will be working on integrating the colour change technology into a suitable dressing and looking at cost effective routes for industrial production

How Nanoparticles Can Cause Lung Damage ? And How The Damage Can Be Blocked?

Scientists have identified for the first time a mechanism by which nanoparticles cause lung damage and have demonstrated that it can be combated by blocking the process involved, taking a step toward addressing the growing concerns over the safety of nanotechnology. Nanotechnology, the science of the extremely tiny (one nanometer is one-billionth of a meter), is an important emerging industry with a projected annual market of around one trillion US dollars by 2015. It involves the control of atoms and molecules to create new materials with a variety of useful functions, including many that could be exceptionally beneficial in medicine. However, concerns are growing that it may have toxic effects, particularly damage to the lungs. Although nanoparticles have been linked to lung damage, it has not been clear how they cause it.

Lung damage is the chief human toxicity concern surrounding nanotechnology, with studies showing that most nanoparticles migrate to the lungs. However, there are also worries over the potential for damage to other organs.

In the study, the researchers first showed, through several independent experiments, that several types of PAMAMs killed human lung cells in the lab. They did not observe any evidence that the cells were dying by apoptosis, a common type of programmed cell death. However, they found that the particles triggered autophagy cell death through the Akt-TSC2-mTOR signaling pathway. Autophagy is a process that degrades damaged materials in a cell and plays a normal part in cell growth and renewal, but scientists have found that sometimes an over activity of this destruction process leads to cell death.

Nanotechnology-Innovations in Medical Technology

New 'nanotweezers' open door to innovations in medicine, mobile tech

As a common technique, the nanotweezers are appropriate to a catholic range of metal, semiconductor, polymer and dielectric nanostructures with charged or hydrophobic surfaces. Thus far, researchers have successfully "trapped" silicon nanospheres, silica beads, polystyrene beads, silicon nanowires, germanium nanowires and metal nanostructures. The further arrangement of these nanomaterials in a rationally designed manner can lead to a better understanding of how matter organizes and potential discovery of new functional materials.

In a biological setting, Zheng believes that live cell manipulation and cell-to-cell communication will probably be a primary research focus for engineers wishing to exploit the capabilities afforded by the nanotweezers.

Optimization of the current system to make it bio-compatible is the next step of our project," Zheng said. "We expect to use our tweezers to manipulate biological cells and molecules at single-molecule resolution, to control drug release and to study the cell-cell interaction. The manipulation and analysis of biological objects will open a new door to early disease diagnosis and the discovery of nanomedicine."

This cooperation between nanophotonics, nanochemistry and nanophysics research has provided the tools to manipulate and analyze nanoparticles in ways that have, until now, been beyond our reach. The UT research team has demonstrated how, using their nanotweezers, light can be used at the nanoscale in the same way mechanical tweezers are used to handle larger samples.

Nanomedicine Drugs can be made smarter

An innovative technique has been established to make drugs smarter using nanotechnology so they will be more operative at reaching their target. Scientists have formulated a new method to decorate gold nanoparticles with a protein of choice so they can be used to tailor drug to more accurately target an area on the body, such as a cancer tumor.

Gold nanoparticles are spheres made of gold atoms having a diameter of only few billionths of a metre which can be coated with a biological protein and combined with drugs to enable the treatment to travel through the body and reach the affected area.

The nanoparticles can adsorb (hold on its surface) drugs which would otherwise become insoluble or quickly degrade in the blood stream, and due to their small size they can overcome biological barriers such as membranes, skin and the small intestine which would usually prevent the drug from reaching its target.

The technology is already used in real world applications such as pregnancy tests -- where gold nanoparticles decorated with an antibody against the hormone present in the urine of pregnant women is added to the 'positive' strip so it reacts with the nanoparticles to turn the stick red -- but is not yet widely used in drug development.ME Conferences inviting the participants all over the globe to share their research at INTERNATIONLAL CONFERENCE ON NANOMEDICINE AND NANOTECHNOLOGY IN HEALTH CARE scheduled during MAY 27-28, 2019, ISTANBUL, TURKEY

NANOMEDICINE MEET 2019

About Conference

ME Conferences invites all the participants from all over the world to attend “Nanomedicine and Nanotechnology in Health Care” during May, 27-28, 2019 at Istanbul,Turkey. This includes prompt keynote presentations, Oral talks, Poster presentations and Exhibitions. And it provides an opportunity to learn about the complexity of the Diseases, discuss interventional procedures, look at new and advances in Nanotechnology and their efficiency and efficacy in diagnosing and treating various diseases and also in Healthcare treatments.

ME Conferences organizes 1000+ Global Events Every Year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open access journals which contains over 1,00,000 eminent personalities, reputed scientists as editorial board and organizing committee members.  ME Conferences journals have over 5 million readers and the fame and success of the same can be attributed to the strong editorial board which contains over 30000 eminent personalities and the rapid, quality and quick review processing.ME Conferences make the perfect platform for global networking as it brings together renowned speakers and scientists across the globe to a most exciting and memorable scientific event filled with much enlightening interactive sessions, international workshops, world class international exhibitions and poster presentations.

Why to attend?

This Conference ”Nanomedicinemeet 2019” will focus on Healthcare and Medicine. World-renowned speakers, the most recent techniques, tactics, and the newest updates in fields Nanotechnology and Engineering, Medical Nanotechnology, Tissue Engineering are hallmarks of this conference. Nanomedicinemeet-2019 is an exciting opportunity to showcase the modern technology, the new products of your company, and/or the service your industry may offer to a broad international audience. It covers a lot of topics and it will be a nice platform to showcase their recent researches on Nanotechnology, Material Science and other interesting topics.

Conference Highlights

• Nanosurgery
• Nanomedicine
• Nanorobots in Medicine
• Nanoparticles in Photodynamic Therapy
• Importance of Nanotechnology in Biosensors
• Green Nanoscience
• Nanotechnology in Biology
• Organic Nanoparticles
• Biological Synthesis of Nanoparticles
• Nanotechnology Based Drug Delivery System
• Nanosuspention Formulation
• Tissue Engineering & Regenerative Medicine
• Polymeric Nanoparticles for Biomedical
• Nanobubble in Nanomedicine
• Natural Product Based Nanomedicine
• Nanotechnology in Food Science
• Toxicity of Nanoparticles
• Nanotechnology-Innovations in Medical Technology

Special Issues

•  All accepted abstracts will be published in respective Supporting International Journals.
•  Abstracts will be provided with Digital Object Identifier by Cross Ref.

See more at:-https://nanomedicine.nanotechconferences.org/